ccg 203971 Search Results


ccg 203971  (MedChemExpress)
93
MedChemExpress ccg 203971
Ccg 203971, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccg 203971/product/MedChemExpress
Average 93 stars, based on 1 article reviews
ccg 203971 - by Bioz Stars, 2026-02
93/100 stars
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ccg  (Selleck Chemicals)
91
Selleck Chemicals ccg
Ccg, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccg/product/Selleck Chemicals
Average 91 stars, based on 1 article reviews
ccg - by Bioz Stars, 2026-02
91/100 stars
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ccg-100602  (Cayman Chemical)
90
Cayman Chemical ccg-100602
Ccg 100602, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
ccg-100602 - by Bioz Stars, 2026-02
90/100 stars
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ccg-203971  (Merck & Co)
90
Merck & Co ccg-203971
<t>CCG-203971</t> reduces the ability of TAM-treated MCF10A-ER-Src cells to sustain proliferation, to grow mammospheres and to invade in collagen. (A) Quantification from three biological replicates of the fold changes in Luciferase activity between MCF10A-ER-Src cells treated with EtOH or TAM, in the presence or absence of CCG-203971, transfected with the SRF-responsive-Luc reporter gene. (B) Quantification from four (left) or three (right) biological replicates of the percentage of MCF10A-ER-Src cells in S-phase, treated for 12 h (left) or 24 h (right) with EtOH or TAM in the presence or absence of CCG-203971. (C,D) (Left) Representative images of MCF10A-ER-Src mammospheres treated for 36 h (C) or 6 h (D) with EtOH or TAM, in the presence or absence of CCG-203971. Scale bars: 50 μm. (Right) Quantification from three biological replicates of the mammosphere-forming efficiency of MCF10A-ER-Src mammospheres treated with EtOH or TAM for 36 h (C) or 6 h (D), in the presence or absence of CCG-203971. (E) (Left) Representative images of MCF10A-ER-Src spheroids in collagen before treatment (0 h) or after 36 h of treatment with EtOH or TAM, in the presence or absence of CCG-203971. The lower images are magnifications of the region delimited by the black outline in the top images. Scale bars: 50 μm. (Top right) Quantification from two biological replicates of the percentage of invading MCF10A-ER-Src spheroids treated with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971 or treated with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. (Bottom right) Quantification from two biological replicates of the circularity of MCF10A-ER-Src spheroids in collagen before treatment (0 h) and after 36 h of treatment with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971, or before treatment (0 h) and after 36 h of treatment with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. Error bars indicate s.d.; ns, non-significant; * P <0.05; ** P <0.01; *** P <0.001; **** P <0.0001. Statistical significance was calculated using unpaired two-tailed Student's t -test (E) or one-way ANOVA with Tukey's multiple comparison (A-D).
Ccg 203971, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccg-203971/product/Merck & Co
Average 90 stars, based on 1 article reviews
ccg-203971 - by Bioz Stars, 2026-02
90/100 stars
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mrtf-a inhibitor ccg-203971  (ApexBio)
90
ApexBio mrtf-a inhibitor ccg-203971
<t>CCG-203971</t> reduces the ability of TAM-treated MCF10A-ER-Src cells to sustain proliferation, to grow mammospheres and to invade in collagen. (A) Quantification from three biological replicates of the fold changes in Luciferase activity between MCF10A-ER-Src cells treated with EtOH or TAM, in the presence or absence of CCG-203971, transfected with the SRF-responsive-Luc reporter gene. (B) Quantification from four (left) or three (right) biological replicates of the percentage of MCF10A-ER-Src cells in S-phase, treated for 12 h (left) or 24 h (right) with EtOH or TAM in the presence or absence of CCG-203971. (C,D) (Left) Representative images of MCF10A-ER-Src mammospheres treated for 36 h (C) or 6 h (D) with EtOH or TAM, in the presence or absence of CCG-203971. Scale bars: 50 μm. (Right) Quantification from three biological replicates of the mammosphere-forming efficiency of MCF10A-ER-Src mammospheres treated with EtOH or TAM for 36 h (C) or 6 h (D), in the presence or absence of CCG-203971. (E) (Left) Representative images of MCF10A-ER-Src spheroids in collagen before treatment (0 h) or after 36 h of treatment with EtOH or TAM, in the presence or absence of CCG-203971. The lower images are magnifications of the region delimited by the black outline in the top images. Scale bars: 50 μm. (Top right) Quantification from two biological replicates of the percentage of invading MCF10A-ER-Src spheroids treated with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971 or treated with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. (Bottom right) Quantification from two biological replicates of the circularity of MCF10A-ER-Src spheroids in collagen before treatment (0 h) and after 36 h of treatment with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971, or before treatment (0 h) and after 36 h of treatment with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. Error bars indicate s.d.; ns, non-significant; * P <0.05; ** P <0.01; *** P <0.001; **** P <0.0001. Statistical significance was calculated using unpaired two-tailed Student's t -test (E) or one-way ANOVA with Tukey's multiple comparison (A-D).
Mrtf A Inhibitor Ccg 203971, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mrtf-a inhibitor ccg-203971/product/ApexBio
Average 90 stars, based on 1 article reviews
mrtf-a inhibitor ccg-203971 - by Bioz Stars, 2026-02
90/100 stars
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Image Search Results


CCG-203971 reduces the ability of TAM-treated MCF10A-ER-Src cells to sustain proliferation, to grow mammospheres and to invade in collagen. (A) Quantification from three biological replicates of the fold changes in Luciferase activity between MCF10A-ER-Src cells treated with EtOH or TAM, in the presence or absence of CCG-203971, transfected with the SRF-responsive-Luc reporter gene. (B) Quantification from four (left) or three (right) biological replicates of the percentage of MCF10A-ER-Src cells in S-phase, treated for 12 h (left) or 24 h (right) with EtOH or TAM in the presence or absence of CCG-203971. (C,D) (Left) Representative images of MCF10A-ER-Src mammospheres treated for 36 h (C) or 6 h (D) with EtOH or TAM, in the presence or absence of CCG-203971. Scale bars: 50 μm. (Right) Quantification from three biological replicates of the mammosphere-forming efficiency of MCF10A-ER-Src mammospheres treated with EtOH or TAM for 36 h (C) or 6 h (D), in the presence or absence of CCG-203971. (E) (Left) Representative images of MCF10A-ER-Src spheroids in collagen before treatment (0 h) or after 36 h of treatment with EtOH or TAM, in the presence or absence of CCG-203971. The lower images are magnifications of the region delimited by the black outline in the top images. Scale bars: 50 μm. (Top right) Quantification from two biological replicates of the percentage of invading MCF10A-ER-Src spheroids treated with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971 or treated with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. (Bottom right) Quantification from two biological replicates of the circularity of MCF10A-ER-Src spheroids in collagen before treatment (0 h) and after 36 h of treatment with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971, or before treatment (0 h) and after 36 h of treatment with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. Error bars indicate s.d.; ns, non-significant; * P <0.05; ** P <0.01; *** P <0.001; **** P <0.0001. Statistical significance was calculated using unpaired two-tailed Student's t -test (E) or one-way ANOVA with Tukey's multiple comparison (A-D).

Journal: Disease Models & Mechanisms

Article Title: Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

doi: 10.1242/dmm.049652

Figure Lengend Snippet: CCG-203971 reduces the ability of TAM-treated MCF10A-ER-Src cells to sustain proliferation, to grow mammospheres and to invade in collagen. (A) Quantification from three biological replicates of the fold changes in Luciferase activity between MCF10A-ER-Src cells treated with EtOH or TAM, in the presence or absence of CCG-203971, transfected with the SRF-responsive-Luc reporter gene. (B) Quantification from four (left) or three (right) biological replicates of the percentage of MCF10A-ER-Src cells in S-phase, treated for 12 h (left) or 24 h (right) with EtOH or TAM in the presence or absence of CCG-203971. (C,D) (Left) Representative images of MCF10A-ER-Src mammospheres treated for 36 h (C) or 6 h (D) with EtOH or TAM, in the presence or absence of CCG-203971. Scale bars: 50 μm. (Right) Quantification from three biological replicates of the mammosphere-forming efficiency of MCF10A-ER-Src mammospheres treated with EtOH or TAM for 36 h (C) or 6 h (D), in the presence or absence of CCG-203971. (E) (Left) Representative images of MCF10A-ER-Src spheroids in collagen before treatment (0 h) or after 36 h of treatment with EtOH or TAM, in the presence or absence of CCG-203971. The lower images are magnifications of the region delimited by the black outline in the top images. Scale bars: 50 μm. (Top right) Quantification from two biological replicates of the percentage of invading MCF10A-ER-Src spheroids treated with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971 or treated with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. (Bottom right) Quantification from two biological replicates of the circularity of MCF10A-ER-Src spheroids in collagen before treatment (0 h) and after 36 h of treatment with EtOH in the absence ( n =6) or presence ( n =7) of CCG-203971, or before treatment (0 h) and after 36 h of treatment with TAM in the absence ( n =11) or presence ( n =10) of CCG-203971. Error bars indicate s.d.; ns, non-significant; * P <0.05; ** P <0.01; *** P <0.001; **** P <0.0001. Statistical significance was calculated using unpaired two-tailed Student's t -test (E) or one-way ANOVA with Tukey's multiple comparison (A-D).

Article Snippet: To assess the effect of preventing actin polymerization or MRTF-A nuclear translocation, cells were grown in CGM for 12-24 h, washed and co-treated with 4OH-TAM or EtOH in the presence or absence of 0.5 µM LatA (Labclinics, 10010630) or of 40 µM CCG-203971 (Merck, SML1422) in restricted growth medium (RGM), composed of DMEM/F12, 0.5% CSHS, 0.5 µg/ml hydrocortisone, 100 ng/ml cholera toxin and 10 µg/ml insulin for the time points indicated.

Techniques: Luciferase, Activity Assay, Transfection, Two Tailed Test